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Zyloprim Warnings and Precautions

If you have liver disease, kidney disease, or any allergies, make sure to let your healthcare provider know before taking Zyloprim. Warnings and precautions also include possible drug interactions, the safety of using the medication while pregnant or breastfeeding, and potentially dangerous (and even life-threatening) side effects. To avoid any complications with Zyloprim, warnings and precautions for the medication should be fully discussed with your healthcare provider.

What Should I Tell My Healthcare Provider Before Taking Zyloprim?

You should talk with your healthcare provider prior to taking Zyloprim® (allopurinol) if you have:
  • Liver disease, such as liver failure, cirrhosis, or hepatitis
  • Kidney disease, such as kidney failure (renal failure)
  • Any allergies, including allergies to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about any other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Zyloprim Warnings and Precautions

Some warnings and precautions to be aware of prior to taking Zyloprim include the following:
  • You should stop taking Zyloprim immediately and contact your healthcare provider if you develop a rash. Sometimes, a rash is the first sign of dangerous reactions to Zyloprim, such as Stevens-Johnson syndrome (a life-threatening skin condition), liver damage, or even death.
  • Zyloprim can cause liver problems that are usually reversible after the medication is stopped. Let your healthcare provider know if you develop any signs of such problems, such as weight loss, appetite loss, itching, and increased liver enzymes. If you already have liver problems, your healthcare provider should periodically test your liver function (using a simple blood test) while you take Zyloprim.
  • Zyloprim can cause drowsiness. Make sure to see how Zyloprim affects you before driving or operating heavy machinery.
  • If you have kidney disease, you may need to be monitored more closely, and you may need a lower Zyloprim dosage.
  • Zyloprim works to prevent gout attacks; it does not help to treat attacks that are already occurring. In fact, it can temporarily worsen gout, especially at first. For these reasons, Zyloprim is usually used along with other gout medications, especially for the first few months.
  • It is important to drink plenty of fluids while taking Zyloprim, in order to help prevent kidney stones from forming.
  • Some people have developed kidney failure while taking Zyloprim. This is more likely to occur in people with cancer or who already have kidney problems.
  • It has been reported that Zyloprim may decrease the bone marrow's ability to produce certain cells. This could possibly lead to anemia (due to decreased red blood cells) or frequent infections (due to decreased white blood cells).
  • Zyloprim may interact with other medications (see Zyloprim Interactions).
  • Zyloprim is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are not currently known (see Allopurinol and Pregnancy).
  • Zyloprim passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, discuss this with your healthcare provider prior to taking the drug (see Allopurinol and Breastfeeding).
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