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Precautions and Warnings With Trospium XR

To help ensure a safe and effective treatment process, it is important to understand the potential risks associated with a medication. Some of the precautions and warnings with trospium XR include potential side effects and the safety of using the drug when pregnant or breastfeeding. Precautions and warnings with trospium XR also extend to people who have difficulty urinating, uncontrolled narrow-angle glaucoma, or digestive problems.

Trospium XR: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking trospium XR (Sanctura® XR) if you have:
  • Digestive problems (especially those than involve slow emptying of food from the stomach)
  • Ulcerative colitis
  • Myasthenia gravis
  • Kidney disease, such as kidney failure (renal failure)
  • Glaucoma
  • Difficulty passing urine
  • An enlarged prostate (also known as benign prostatic hyperplasia, or BPH)
  • Any allergies, including allergies to food, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about any other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings With Trospium XR

Some of the warnings and precautions to be aware of prior to taking trospium XR include the following:
  • In rare cases, this medication can cause life-threatening swelling of the face, lips, tongue, or throat. This can occur quickly, even after the first dose. Seek immediate medical attention if such swelling occurs.


  • You should not take trospium XR if you have severe kidney disease. Also, it is not known if trospium XR is safe for people with mild or moderate kidney disease.
  • Trospium XR can cause blurred vision, dizziness, and drowsiness. Be sure to see how trospium XR affects you before driving a car or operating heavy machinery.
  • Trospium XR can slow down the digestive system. This can cause problems, especially for people who already have a slow digestive system due to myasthenia gravis, ulcerative colitis, or other problems.
  • This medication can make glaucoma worse. If you have glaucoma and take trospium XR, your healthcare provider may need to monitor you more closely.
  • Trospium XR may potentially interact with a number of other medications (see Drug Interactions With Trospium XR).
  • Trospium XR is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are not known (see Sanctura XR and Pregnancy).
  • It is not known whether trospium XR passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, discuss this with your healthcare provider prior to taking the drug (see Sanctura XR and Breastfeeding).
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