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Precautions and Warnings With Tolterodine

Specific Precautions and Warnings With Tolterodine

Warnings and precautions to be aware of prior to taking tolterodine include the following:
  • In studies, high doses of tolterodine (twice the usual dose) increased the risk of a potentially dangerous irregular heart rhythm called QT prolongation. If you already have an arrhythmia (especially long QT syndrome), tolterodine may make it worse.
  • This medication may make glaucoma worse. If you have glaucoma and take tolterodine, your healthcare provider may need to monitor you more closely.
  • The kidneys and liver help remove tolterodine from your body. Therefore, if you have kidney or liver disease, you may require extra monitoring by your healthcare provider and may need to take a lower tolterodine dosage.
  • Tolterodine can cause blurred vision, dizziness, and drowsiness. Make sure you know how the drug affects you before driving or operating heavy machinery.


  • If you have a condition known as myasthenia gravis, make sure to check with your healthcare provider before taking tolterodine, as it can worsen this condition.


  • Tolterodine may potentially interact with a number of other medications (see Drug Interactions With Tolterodine).
  • Tolterodine is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are not known (see Detrol and Pregnancy).
  • It is not known whether tolterodine passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Detrol and Breastfeeding).
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