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Drug Interactions With Tolterodine

Tolterodine Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when tolterodine is combined with any of the drugs listed above.
Acetylcholinesterase Inhibitor Medications
Taking tolterodine with an acetylcholinesterase inhibitor can make both medications less effective. Your healthcare provider may need to monitor you more closely and adjust your dose of these medications to prevent interactions from occurring.
Anticholinergic Drugs
Combining an anticholinergic medication with tolterodine (which is also an anticholinergic medication) can increase your risk of side effects of tolterodine, such as dry mouth, constipation, dry eyes, or difficulty passing urine.
Certain Antifungals or Antibiotics
Some antibiotic or antifungal medications may increase the level of tolterodine in your blood. Your healthcare provider may recommend that you take a lower tolterodine dosage if you are taking certain antibiotics or antifungals.
Taking cyclosporine and tolterodine together can increase the level of tolterodine in your blood. If you are taking cyclosporine, your healthcare provider may recommend that you take a lower dose of tolterodine.
QT-Prolonging Medications
Studies have suggested that high doses of tolterodine (at least twice the recommended dose) can increase the risk of an irregular heart rhythm called QT prolongation. Therefore, combining tolterodine with QT-prolonging medications may increase this risk. Talk with your healthcare provider before taking these medications together.
Both pramlintide and anticholinergic medications (including tolterodine) can slow down the movement of food through the digestive tract. Taking them together can increase the risk of constipation or nausea. Talk with your healthcare provider before combining these medications.
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