Drug Interactions With Tolterodine ER

Acetylcholinesterase inhibitors, QT-prolonging medications, and certain antibiotics or antifungals may potentially cause drug interactions with tolterodine ER. These interactions can increase your risk of developing side effects and may decrease the effectiveness of the medicines. You can reduce your risk for drug interactions with tolterodine ER by telling your healthcare provider about all other medications you are taking, including non-prescription medications.

Drug Interactions With Tolterodine ER: An Overview

Tolterodine ER (Detrol LA®) can potentially interact with a few other medicines. Some of the medicines that may lead to tolterodine ER drug interactions include:
 
  • Acetylcholinesterase inhibitors, such as:
 
 
  • Anticholinergic medications, such as:
 
 
  • Certain antibiotics or antifungals, such as:
 
    • Clarithromycin (Biaxin®)
    • Erythromycin (Ery-Tab®)
    • Isoniazid (Nydrazid®)
    • Itraconazole (Sporanox®)
    • Ketoconazole (Nizoral®)
    • Telithromycin (Ketek®)
 
  • Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
  • Medications that cause an irregular heart rhythm called QT prolongation (see QT-Prolonging Medications for a more detailed list), such as:
 
 
 
 
  • Vinblastine.
     

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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