Drug Interactions With Tolterodine ER (Cont.)

Tolterodine ER Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when tolterodine ER is combined with any of the drugs listed above.
 
Acetylcholinesterase Inhibitors
Taking tolterodine ER with an acetylcholinesterase inhibitor can make both medications less effective. Your healthcare provider may need to monitor you more closely and adjust your dose of these medications.
 
Anticholinergic Medications
Taking an anticholinergic medication with tolterodine ER (which is also an anticholinergic medication) can increase your risk for side effects of tolterodine ER, such as dry mouth, constipation, dry eyes, or difficulty passing urine.
 
Certain Antibiotics or Antifungals
Some antibiotic or antifungal medications may increase the level of tolterodine ER in your blood. Your healthcare provider may recommend that you take a lower tolterodine ER dosage if you are taking certain antibiotics or antifungals.
 
Cyclosporine
Taking cyclosporine and tolterodine ER together can increase the level of tolterodine ER in your blood. If you are taking cyclosporine, your healthcare provider may recommend that you take a lower dose of tolterodine ER.
 
QT-Prolonging Medications
Studies have suggested that high tolterodine ER dosages (twice the recommended dose) can increase the risk of an irregular heart rhythm called QT prolongation. Therefore, combining tolterodine ER with QT-prolonging medications may increase this risk. Talk with your healthcare provider before taking these medications together.
 
Pramlintide
Both pramlintide and anticholinergic medications (including tolterodine ER) can slow down the movement of food through the digestive tract. Taking them together can increase the risk of constipation or nausea. Talk with your healthcare provider before taking these medications together.
(Drug Interactions With Tolterodine ER Continued: Page 3)

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;