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Testosterone Pellet Side Effects
Headaches, hair loss, and changes in sex drive are some of the possible side effects of testosterone pellets. Although many reactions to this prescription medication are typically minor, some potentially serious problems can occur during treatment. For example, if you develop abnormal bleeding, depression, or unexplained swelling, contact your healthcare provider right away.
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Just like any medicine, testosterone pellets (Testopel®) can cause side effects. However, not everyone who uses the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible testosterone pellet side effects. Your healthcare provider can discuss a more complete list with you.)
Some side effects of testosterone pellets are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
- Severe or persistent pain or swelling, or any pus at the injection site
- Frequent or persistent erections of the penis
- Nausea or vomiting
- Yellowing of the skin or whites of the eyes (jaundice)
- Changes in mood, such as depression or anxiety
- Swelling in your body, especially your legs, ankles, or feet
- Changes in liver enzymes
- Increases in red blood cells
- Abnormal bruising or bleeding
- Changes in cholesterol
- Difficulty urinating, painful urination, or blood in the urine
- Signs of an allergic reaction, such as:
- An unexplained rash
- Hives
- Itching
- Unexplained swelling, especially of the mouth, lips, or throat
- Wheezing
- Difficulty breathing or swallowing.
Written by/reviewed by: Susan Lakey, PharmD, MPH
Last reviewed by: Kristi Monson, PharmD



