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Drug Interactions With Testosterone Pellets

If insulin, warfarin, corticosteroids, or certain other drugs are used in combination with testosterone pellets, interactions can occur. In some cases, these negative reactions can cause fluid retention (edema) or dangerous bleeding. To help ensure a safe treatment and prevent complications, your healthcare provider may need to adjust your dosages or monitor you more closely.

An Overview of Testosterone Pellet Interactions

The testosterone pellet (Testopel®) may react with a number of other medications. Some of the drugs that can lead to interactions with testosterone pellets include but are not limited to:
  • Corticosteroids, such as:
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Orapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)

More Detail on Drug Interactions With Testosterone Pellets

The following sections explain in detail the potentially negative interactions that can occur when testosterone pellets are combined with any of the drugs listed above.
Combining testosterone pellets with a corticosteroid may increase the risk for fluid retention (edema), which could be a serious problem in people with heart, kidney, or liver disease. Talk to your healthcare provider before using these drugs together.
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Testosterone Pellet Information

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