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Precautions and Warnings With Teriparatide

Knowing the precautions and warnings with teriparatide prior to starting the drug can help ensure a safe treatment process. Before taking the medicine, let your healthcare provider know if you have bone cancer, heart disease, or high blood calcium. Since teriparatide has not been studied for long-term use, precautions and warnings with teriparatide recommend not using it for more than two years.

Teriparatide: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking teriparatide (Forteo™) if you have:
 
  • High blood calcium (hypercalcemia)
  • Unexplained high alkaline phosphate levels in the blood
  • Paget's disease of the bone
  • Undergone radiation treatments
  • Bone cancer (or have had bone cancer in the past)
  • Kidney disease, liver disease, or heart disease
  • Any allergies, including allergies to food, dyes, or preservatives.
     
Also, let your healthcare provider know if you are:
 
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
     
Make sure to tell your healthcare provider about all other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
 

Specific Precautions and Warnings With Teriparatide

Warnings and precautions to be aware of prior to taking teriparatide include the following:
 
  • Teriparatide increases the risk of bone cancer in rats. The risk increased with the dosage and the duration of teriparatide use. It is not known whether teriparatide also increases the risk of bone cancer in humans. You may be more susceptible to bone cancer (and, therefore, should not take teriparatide) if you:
 
    • Have Paget's disease of the bone
    • Have unexplained high alkaline phosphate levels in the blood
    • Are a child whose bones are still growing
    • Have had radiation therapy that affected your skeleton.
 
  • The medication can increase the level of calcium in your blood. Therefore, you should not take teriparatide if you already have high blood calcium (known medically as hypercalcemia).
     
  • Teriparatide has not been studied for long-term use (more than two years). At this time, people are generally advised to limit their use of the drug to two years or less.
     
  • The medication can cause lightheadedness, dizziness, or fainting, usually during the first few doses. You should be sitting down for your first few teriparatide doses just in case you faint.
     
  • Teriparatide has not been adequately studied in people with kidney, liver, or heart disease. Talk to your healthcare provider before taking the drug if you have any of these problems.
     
  • Teriparatide can potentially interact with a few other medications (see Drug Interactions With Teriparatide).
     
  • Teriparatide is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy (see Forteo and Pregnancy).
     
  • It is not known whether teriparatide passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Forteo and Breastfeeding).
     
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