Tacrine Interactions Explained
The following sections explain in detail the potentially negative interactions that can occur when
tacrine is combined with any of the drugs listed above.
Anticholinergic Medications
Anticholinergic medications and tacrine work in opposite ways, and taking such medications could make both less effective. Check with your healthcare provider before combining an anticholinergic medication with tacrine.
Cholinergic Drugs
Taking tacrine with other cholinergic drugs could increase the risk of side effects. Do not use these medications together without your healthcare provider's approval and supervision.
Cimetidine (Tagamet)
Cimetidine may increase the level of tacrine in your blood, increasing your risk of tacrine side effects. If you take tacrine, cimetidine is probably not a good choice for you.
Ciprofloxacin (Cipro)
Ciprofloxacin may increase the level of tacrine in your blood, increasing your risk of side effects. Check with your healthcare provider before taking ciprofloxacin with tacrine.
Fluvoxamine (Luvox)
Fluvoxamine may greatly increase the level of tacrine in your blood, increasing your chance of dangerous side effects. Do not take fluvoxamine and tacrine together without your healthcare provider's approval and supervision.
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Combining tacrine with an
NSAID may increase the risk of stomach or intestinal ulcers. Check with your healthcare provider before taking tacrine with any NSAID (including non-prescription NSAIDs).
Theophylline (Uniphyl, Theocron, TheoCap, Theo-24, Elixophyllin)
Tacrine can increase the level of
theophylline in your blood, causing problems. If you take theophylline and tacrine together, your healthcare provider should monitor the level of theophylline in your blood and adjust your
theophylline dosage as necessary.
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