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Synvisc-One Warnings and Precautions

Before you start treatment with Synvisc-One, your healthcare provider needs information on your current medical condition and any drugs you are taking; this will help ensure a safe treatment process. Warnings and precautions for Synvisc-One relate to things like avoiding this product if you have a knee infection and being aware that it may cause problems in people who are allergic to feathers or eggs.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to receiving your injection of Synvisc-One® (Hylan G-F 20) if you have:
  • A swollen leg, ankle, or foot
  • Circulatory problems (such as blood clots) in the legs
  • An infection in or around the knee
  • Any allergies, including to food, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking about becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings With Synvisc-One

Warnings and precautions to be aware of prior to receiving your injection include the following:
  • Your healthcare provider should not inject any medications (such as steroids or anesthetics) into the knee joint along with Synvisc-One, as this would dilute Synvisc-One and make it less effective. It is okay for your healthcare provider to inject a local anesthetic to help numb the area prior to the injection.
  • If you are allergic to any bird products, such as feathers or eggs, you might also be allergic to Synvisc-One, since it is made from chicken combs.
  • In the United States, Synvisc-One is not approved for injection into any other joint except the knees.
  • This product should not be injected into the bloodstream or anywhere else except the knee joint.
  • Synvisc-One should be used with caution if you have swelling or circulation problems of the leg, ankle, or foot.
  • It is unknown if Synvisc-One passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to receiving your injection (see Synvisc-One and Breastfeeding).
  • It is unknown if Synvisc-One is safe for use during pregnancy (see Synvisc-One and Pregnancy).
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