Drug Interactions With Solifenacin Succinate

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• Acetylcholinesterase inhibitor medications, such as:

• Donepezil (Aricept^®)
• Galantamine (Razadyne™)
• Rivastigmine (Exelon^®)
• Tacrine (Cognex^®)

• Anticholinergic drugs, such as:

• Atropine
• Belladonna (Donnatal^®, B&O Supprettes^®, Bellamine S^®)
• Benztropine (Cogentin^®)
• Clidinium (Librax^®)
• Clozapine (Clozaril^®)
• Darifenacin (Enablex^®)
• Dicyclomine (Bentyl^®)
• Diphenhydramine (Benadryl^®, Tylenol PM^®)
• Glycopyrrolate (Robinul^®)
• Haloperidol (Haldol^®)
• Homatropine (Hycodan^®)
• Hyoscyamine (Levsin^®)
• Ipratropium (Atrovent^®)
• Oxybutynin (Ditropan^®, Ditropan XL^®, Oxytrol^®)
• Scopolamine (Transderm Scop^®)
• Tiotropium (Spiriva^®)
• Tolterodine (Detrol^®, Detrol^® LA)
• Trospium (Sanctura^®)

• Certain antifungals or antibiotics, such as:

• Clarithromycin (Biaxin^®)
• Erythromycin (Ery-Tab^®)
• Isoniazid (Nydrazid^®)
• Itraconazole (Sporanox^®)
• Ketoconazole (Nizoral^®)
• Telithromycin (Ketek^®)

• Medications that cause an irregular heart rhythm called QT prolongation (see QT-Prolonging Medications), such as:

• Alfuzosin (Uroxatral^®)
• Amoxapine
• Apomorphine (Apokyn^®)
• Chloroquine (Aralen^®)
• Certain anesthetics
• Certain antibiotics
• Certain arrhythmia medications
• Certain cancer medications
• Certain nausea and vomiting medications
• Certain phenothiazine or antipsychotic medications
• Cisapride (Propulsid^®)
• Cyclobenzaprine (Flexeril^®, Fexmid™)
• Maprotiline (Ludiomil^®)
• Methadone (Dolophine^®)
• Octreotide (Sandostatin^®)
• Pentamidine (NebuPent^®, Pentam^®)
• Ranolazine (Ranexa^®)
• Tacrolimus (Prograf^®)
• Vardenafil (Levitra^®, Staxyn™)

• Pramlintide (Symlin^®)
• Protease inhibitors, such as:

• Amprenavir (Agenerase^®)
• Atazanavir (Reyataz^®)
• Fosamprenavir (Lexiva^®)
• Indinavir (Crixivan^®)
• Nelfinavir (Viracept^®)
• Ritonavir (Norvir^®)
• Saquinavir (Invirase^®).