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Drug Interactions With Solifenacin Succinate

Solifenacin Succinate Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when solifenacin succinate is combined with any of the drugs listed above.
Acetylcholinesterase Inhibitor Medications
Taking solifenacin succinate with an acetylcholinesterase inhibitor can make both medications less effective. Your healthcare provider may need to monitor you more closely and adjust your dose of these medications to prevent interactions from occurring.
Anticholinergic Drugs
Combining an anticholinergic medication with solifenacin succinate (which is also an anticholinergic medication) can increase your risk of side effects of solifenacin succinate, such as dry mouth, constipation, dry eyes, or difficulty passing urine.
Certain Antifungals or Antibiotics
Some antibiotic or antifungal medications may increase the level of solifenacin succinate in your blood. Your healthcare provider may recommend that you take a lower dose of solifenacin succinate if you are taking certain antibiotics or antifungals.
Both pramlintide and anticholinergic medications (including solifenacin succinate) can slow down the movement of food through the digestive tract. Therefore, taking them together can increase the risk of constipation or nausea. Talk with your healthcare provider before combining these medications.
Protease Inhibitors
Protease inhibitors may increase the level of solifenacin succinate in your blood. Your healthcare provider may recommend that you take a lower solifenacin succinate dosage if you are taking a protease inhibitor.
QT-Prolonging Medications
Studies have suggested that high doses of solifenacin succinate can increase the risk of an irregular heart rhythm called QT prolongation. Therefore, combining solifenacin succinate with other QT-prolonging medications may increase this risk. Talk with your healthcare provider before taking these medications together.
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