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Raloxifene Side Effects

In clinical studies of raloxifene, problems that were reported the most often included hot flashes, flulike symptoms, and water retention. Side effects are usually mild and easily treated. However, some side effects of raloxifene are potentially serious. Contact your healthcare provider right away if you experience unexplained uterine bleeding, a sudden rash or swelling, or signs of a stroke.

An Introduction to Raloxifene Side Effects

As with any medicine, side effects are possible with raloxifene hydrochloride (Evista®); however, not everyone who takes the drug will experience problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can be treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with raloxifene. Your healthcare provider can discuss a more complete list with you.)

Serious Side Effects of Raloxifene

Some raloxifene side effects, while occurring infrequently, are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
  • Signs of a blood clot in the leg, such as:
    • Pain in the calf
    • Leg cramps
    • Leg or foot swelling
  • Signs of a blood clot in the lung, such as:
    • Shortness of breath
    • Sharp chest pain
    • Coughing up blood
    • Vision or speech changes
    • Weakness or numbness in an arm or leg
    • Severe headache
  • Sudden loss of vision or vision changes, which can be a sign of a blood clot in the eye
  • High triglycerides
  • Depression (see Evista and Depression)
  • Gallstones or other gallbladder problems
  • Any unusual uterine bleeding
  • Signs of an allergic reaction, including:
    • Unexplained rash
    • Hives
    • Itching
    • Unexplained swelling.
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