What Should I Tell My Healthcare Provider Before Taking Raloxifene?You should talk with your healthcare provider prior to taking this medication if you have:
- Ever had a blood clot, including blood clots in the legs, eyes, or lungs
- Had a stroke or "mini-stroke" (a transient ischemic attack, or TIA)
- Congestive heart failure (CHF)
- High blood pressure (hypertension)
- Liver disease, such as liver failure, cirrhosis, or hepatitis
- Kidney disease, such as kidney failure (renal failure)
- High triglycerides
- Any allergies, including allergies to food, dyes, or preservatives.
Also, let your healthcare provider know if you:
- Smoke cigarettes
- Have not gone through menopause
- Have an upcoming surgery
- Are pregnant or thinking of becoming pregnant (see Evista and Pregnancy)
- Are breastfeeding (see Evista and Breastfeeding).
Make sure to tell your healthcare provider about all medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Raloxifene to learn more, including information on who should not take the drug.)
How Does It Work?Raloxifene belongs to a group of medications called selective estrogen receptor modulators (SERMs). SERMs have both estrogenic (estrogen-like) effects and anti-estrogen effects. Raloxifene has anti-estrogen effects on the breasts, while it has estrogen-like effects on bones (helping to strengthen them).
Many breast cancers are sensitive to the estrogen hormone, meaning that the tumor grows with the help of it. Raloxifene binds to estrogen receptors in the breast, preventing the hormone from binding. By decreasing the effects of estrogen, Evista can help reduce the risk of developing breast cancer.