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Precautions and Warnings With Raloxifene

Specific Precautions and Warnings With Raloxifene

Warnings and precautions to be aware of prior to taking raloxifene include the following:
  • The medication can increase the risk of blood clots. You are at higher risk for blood clots if your mobility is limited due to surgery, bed rest, or traveling. In order to help prevent blood clots, raloxifene should be stopped at least three days before any surgery that will limit your mobility. While traveling, make sure that you try to move about periodically to keep the blood flowing through your legs. If you have a condition that may predispose you to blood clots (such as cancer or congestive heart failure), your healthcare provider should weigh the benefits of raloxifene against the risks of a blood clot.
  • In one study of raloxifene in women with heart disease (or who were at high risk for heart problems), the medication increased the risk of death due to strokes. If you already have risk factors for a stroke (such as a prior stroke or mini-stroke, a heart arrhythmia, high blood pressure, or cigarette smoking), your healthcare provider should weigh the risk of a stroke against the benefits of raloxifene.
  • Raloxifene should not be used to treat or prevent heart disease. Studies have shown that the drug is not effective for this use.
  • Raloxifene has not been adequately studied in premenopausal women or in men. Also, the medication has not been adequately studied in women who have already had breast cancer.
  • The medication may have negative effects on the lining of the uterus. Tell your healthcare provider if you experience any unusual uterine bleeding while taking raloxifene.
  • It is important to understand that raloxifene does not prevent all cases of breast cancer. Report any breast changes to your healthcare provider immediately.
  • Some women have a tendency to develop high triglycerides while taking an estrogen medication. Even though raloxifene is not an estrogen medication, it can act like estrogen in some ways. The drug may cause high triglycerides, especially in women who have a history of high triglycerides due to estrogen.
  • Let your healthcare provider know if you have liver or kidney disease, as your body may not handle raloxifene as well as it should.
  • Raloxifene can potentially interact with a number of medications (see Drug Interactions With Raloxifene).
  • Raloxifene is considered a pregnancy Category X medication. This means that it is dangerous for use during pregnancy (see Evista and Pregnancy).
  • It is not known whether raloxifene passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Evista and Breastfeeding).
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