Drug Interactions With Raloxifene
Bile Acid Sequestrants
Bile acid sequestrant medications may bind to raloxifene in the digestive tract, preventing it from being absorbed into the body. This may make raloxifene less effective. Do not take raloxifene and a bile acid sequestrant at the same time. It is best to take these medications at least several hours apart.
Theoretically, raloxifene may interact with diazepam, since both medications are highly bound to proteins in the blood. However, since this interaction has not actually been studied, it is not known if taking these medications together will cause any problems. Your healthcare provider may choose to monitor you more closely in such a case.
Raloxifene works like estrogen in some ways and like an anti-estrogen in other ways. As a result, it is possible that estrogen medications may make raloxifene less effective or may increase the risk of certain raloxifene side effects. Therefore, taking raloxifene with an estrogen is not recommended.
There have been reports that raloxifene may make thyroid medications less effective, although this has not been confirmed in formal studies. Your healthcare provider may decide to monitor you more closely if you are taking both of these medications.
If you are taking both warfarin and raloxifene, your healthcare provider may need to monitor your prothrombin time ("pro time" -- a blood test to monitor people on warfarin) more closely, especially when you are starting or stopping raloxifene.