Senior Health Channel
Topics & Medications
Quicklinks
Related Channels

Precautions and Warnings With Pramipexole ER

You may not be able to use pramipexole ER if you have certain medical conditions, such as kidney disease, low blood pressure, or certain allergies. Being aware of these and other precautions and warnings that apply to you can help ensure a safe treatment process with pramipexole ER, so make sure your healthcare provider has a list of all medications you are taking and any medical conditions you have.

What Should I Tell My Healthcare Provider Before Taking Pramipexole ER?

You should talk with your healthcare provider prior to taking pramipexole ER (Mirapex® ER™) if you have:
 
  • Kidney disease, including kidney failure (renal failure) or milder forms of kidney disease
  • Low blood pressure (hypotension)
  • Dyskinesia (a muscle movement disorder)
  • Any allergies, including to foods, dyes, or preservatives.
     
Also, let your healthcare provider know if you are:
 
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
     
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
 

Specific Pramipexole ER Precautions and Warnings

Some of the warnings and precautions to be aware of prior to taking this drug include the following:
 
  • The medication may cause you to fall asleep during the day, sometimes without warning. This can be especially dangerous if you are driving a car or operating heavy machinery. In addition, this can happen long after you start taking pramipexole ER. Ask your healthcare provider if you should stop driving a car or operating heavy machinery while taking pramipexole ER.
     
  • Pramipexole ER can cause low blood pressure, especially when standing or sitting up too quickly. Take your time getting up, and let your healthcare provider know if you experience fainting or frequent dizziness.
     
  • The medication can cause hallucinations. This side effect is most common in people taking pramipexole ER for Parkinson's disease and in elderly people. It is not a rare side effect; in some studies, up to 5 percent of people taking pramipexole ER experienced hallucinations. Let your healthcare provider know if you develop hallucinations while taking the drug. Also, let your friends, family, or caretakers know about this potential side effect, as they may be better able to identify the problem.
     
  • There has been one case of rhabdomyolysis (a breakdown of muscle tissue that can lead to kidney damage) that may have been caused by the short-acting version of pramipexole ER. Make sure to report any severe muscle pain or weakness to your healthcare provider.
     
  • Pramipexole ER can worsen dyskinesia (a movement disorder that is a common side effect of levodopa, another Parkinson's medication). If you take pramipexole ER with a medication that contains levodopa (Parcopa®, Sinemet®, Sinemet® CR, Stalevo®), your healthcare provider may need to decrease your levodopa dosage.
     
  • In animal studies, pramipexole ER caused damage to the retinas of the eyes in rats. Similar problems have been reported in human studies, but it is unclear if the risks are greater in people taking the drug, compared to the general public.
     
  • Medications similar to pramipexole ER can cause serious problems if they are stopped too quickly. Signs of such problems include high fever, stiff muscles, and an altered state of consciousness. Although these problems have not been reported with pramipexole ER, the possibility cannot be ruled out.
     
  • The kidneys remove pramipexole ER from the body. Therefore, if your kidneys are not functioning well, your healthcare provider may recommend a lower pramipexole ER dosage.
     
  • Medications similar to pramipexole ER can cause serious lung, chest, and heart problems as the result of excessive formation of fibrous connective tissue. Rare cases of such problems have been reported with pramipexole ER, but it is not clear if these problems were caused by the drug or something else.
     
  • People with Parkinson's disease have a higher risk of melanoma (a type of skin cancer). It is not known if this is due to Parkinson's disease medications or to other factors. Although pramipexole ER does not seem to increase the risk of melanoma, it cannot be ruled out, and regular skin cancer screenings are recommended.
     
  • There have been a few reports of unusual compulsive behaviors, such as gambling, compulsive buying, or hypersexuality, in people taking pramipexole ER (see Mirapex ER and Impulse Control). Let your healthcare provider know if you develop any such behaviors while taking the drug. Also, let your friends, family, or caretakers know about this potential side effect, as they may be better able to identify the problem.
     
  • Pramipexole ER can potentially interact with several medications (see Drug Interactions With Pramipexole ER).
     
  • Pramipexole ER is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are not known (see Mirapex ER and Pregnancy).
     
  • It is not known whether pramipexole ER passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, discuss this with your healthcare provider prior to taking the drug (see Mirapex ER and Breastfeeding).
     
Ways to Prep Your Kitchen to Eat Well During Cancer Treatment

Pramipexole ER Drug Information

Referring Pages:
Terms of Use
Advertise with Us
Contact Us
About eMedTV
Privacy Policy
Copyright © 2006-2017 Clinaero, Inc.
eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind. Site users seeking medical advice about their specific situation should consult with their own physician. Click Terms of Use for more information.