Drug Interactions With Polyethylene Glycol Electrolyte Solution and Bisacodyl

Diuretics, antacids, and nonsteroidal anti-inflammatory drugs may cause negative interactions with polyethylene glycol electrolyte solution. When these medications are combined, they may increase the risk for potentially serious problems, such as seizures or heart rhythm problems. To ensure a safe treatment process, make sure your healthcare provider is aware of any other medications you are taking, including nonprescription medicines and supplements.

An Overview of Polyethylene Glycol Electrolyte Solution and Bisacodyl Interactions

Polyethylene glycol electrolyte solution and bisacodyl (HalfLytely® and Bisacodyl) is a prescription medication approved to empty the bowels before a colonoscopy. This product may potentially interact with many other medications.
 
Some of the medications that may lead to polyethylene glycol electrolyte solution and bisacodyl drug interactions include but are not limited to:
 
  • Angiotensin-converting enzyme inhibitors (ACE inhibitors), such as:
 
 
  • Angiotensin II receptor blockers (ARBs), such as:

 

  
  • Antacids (Alternagel®, Gaviscon®, Maalox®, Mylanta®, Tums®, and many others)
  • Diuretics, such as:
 
 
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
 
 
  • Oral medications taken within one hour of the first dose of polyethylene glycol electrolyte solution and bisacodyl.
 
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Written by/reviewed by: Susan Lakey, PharmD, MPH
Last reviewed by: Kristi Monson, PharmD
 
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