Oxybutynin Drug Interactions (Cont.)

Oxybutynin Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when oxybutynin is combined with any of the drugs listed above.
 
Acetylcholinesterase Inhibitors
Taking oxybutynin with an acetylcholinesterase inhibitor can make both medications less effective. Your healthcare provider may need to monitor you more closely and adjust your dose of these medications.
 
Anticholinergic Medications
Combining an anticholinergic medication with oxybutynin (which is also an anticholinergic drug) can increase your risk of oxybutynin side effects, such as dry mouth, constipation, dry eyes, or difficulty passing urine.
 
Certain Antifungals or Antibiotics
Some antibiotic or antifungal medications may increase the level of oxybutynin in your blood. Your healthcare provider may recommend that you take a lower oxybutynin dosage if you are taking certain antibiotics or antifungals.
 
Pramlintide
Both pramlintide and anticholinergic medications (including oxybutynin) can slow down the movement of food through the digestive tract. Therefore, taking them together can increase the risk of constipation or nausea. Talk with your healthcare provider before taking these medications together.
 
Protease Inhibitors
Protease inhibitors may increase the level of oxybutynin in your blood. Your healthcare provider may recommend that you take a lower oxybutynin dosage if you are taking a protease inhibitor.
 

Final Thoughts on Oxybutynin Drug Interactions

It is possible that not all oxybutynin drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the specific drug interactions that may apply to you.
 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;