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Precautions and Warnings With Oxybutynin Gel

Before starting a new medication, make sure you know about the drug's precautions and warnings. With oxybutynin gel, you should know that it may slow down the digestive system, cause blurred vision or drowsiness, and worsen glaucoma. Warnings also extend to people who have difficulty urinating, uncontrolled narrow-angle glaucoma, or a condition that delays the emptying of food from the stomach.

What Should I Tell My Healthcare Provider Before Taking Oxybutynin Gel?

You should talk with your healthcare provider prior to taking oxybutynin gel (Gelnique) if you have:
  • Difficulty passing urine
  • An enlarged prostate (also known as benign prostatic hyperplasia, or BPH)
  • Liver disease, including liver failure, cirrhosis, or hepatitis
  • Kidney disease, such as kidney failure (renal failure)
  • Glaucoma
  • Digestive problems (especially problems that cause a slowing of food through the digestive tract)
  • Gastroesophageal reflux disease (GERD)
  • Any allergies, including allergies to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about any other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings

Some oxybutynin gel warnings and precautions to be aware of include the following:
  • In rare cases, this medication can cause life-threatening swelling of the face, lips, tongue, or throat. This can occur quickly, even after the first dose. Seek immediate medical attention if such swelling occurs.


  • Oxybutynin gel could transfer from one person to another if vigorous skin-to-skin contact occurs (such as during sexual intercourse). In order to prevent this, cover the application with clothing once the gel has dried.
  • Oxybutynin gel is flammable. Avoid smoking or open flame until the gel has dried.
  • Oxybutynin gel can slow down the digestive system. This can cause problems, especially for people who already have a slow digestive system due to other medical problems.
  • This medication can make glaucoma worse. If you have glaucoma and take oxybutynin gel, your healthcare provider may need to monitor you more closely.
  • The kidneys and liver help to remove oxybutynin gel from your body. If you have kidney or liver disease, you may require extra monitoring by your healthcare provider and may need to take a lower oxybutynin gel dosage.
  • Oxybutynin gel can cause blurred vision, dizziness, and drowsiness. Make sure to see how oxybutynin gel affects you before driving or operating heavy machinery.
  • Oxybutynin gel can decrease your ability to sweat, which may increase your risk of heat stroke. Make sure to stay well hydrated in the heat.
  • Oxybutynin gel may potentially interact with a number of other medications (see Drug Interactions With Oxybutynin Gel).
  • Oxybutynin gel is considered a pregnancy Category B medication. This means that it is probably safe for use during pregnancy, although the full risks are not known (see Gelnique and Pregnancy).
  • It is not known whether oxybutynin gel passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, discuss this with your healthcare provider prior to taking the drug (see Gelnique and Breastfeeding).
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Oxybutynin Gel Information

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