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Nitroglycerin Drug Interactions

Alcohol
Combining alcohol with nitroglycerin may increase the risk for low blood pressure (hypotension). Check with your healthcare provider before drinking alcohol while using this medication.
 
Alteplase
Based on reports of a drug interaction with intravenous (IV) nitroglycerin, it is possible that nitroglycerin can decrease the level of alteplase in the bloodstream, perhaps making it less effective. In the event that you need alteplase, which is sometimes used for people who are having a heart attack, blood clots, or certain types of strokes, make sure your healthcare provider knows you have been using nitroglycerin.
 
Aspirin
At high dosages, aspirin can increase the level of nitroglycerin in the bloodstream. This means that taking aspirin while using nitroglycerin could increase the risk for nitroglycerin side effects. Check with your healthcare provider before combining these medications.
  
Blood Pressure Medications
Combining nitroglycerin with blood pressure medications may cause dangerously low blood pressure. Your blood pressure may need to be closely monitored if you take these medications together.
 
Ergot Medications
Ergot medications can make nitroglycerin less effective at relieving chest pain (angina). Also, nitroglycerin may increase the level of ergot medications in the blood, increasing the risk for ergot side effects. In general, this combination of medications should be avoided if possible.
 
Phosphodiesterase Type-5 (PDE5) Inhibitors
If you are using nitroglycerin, you cannot take a PDE5 inhibitor, as dangerously low blood pressure may result. You cannot take these medications even within a few days of each other.
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Nitroglycerin Drug Information

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