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Nitroglycerin Dosage

Nitroglycerin Dose for Angina Prevention

Nitroglycerin ointment 2% ointment (Nitro-Bid) and nitroglycerin patches (Minitran, Nitro-Dur) are approved for preventing attacks of chest pain. The standard starting dosage of nitroglycerin patches for the prevention of angina attacks is one 0.2 mg/hour, 0.3 mg/hour, or 0.4 mg/hour patch applied once a day and removed 12 to 14 hours later.
The standard starting dosage for Nitro-Bid for the prevention of angina attacks is half an inch (approximately 7.5 mg of nitroglycerin) applied twice daily, with the first dose in the morning and the second dose six hours later. If this amount is not effective at preventing chest pain, your healthcare provider can double it (and even double it a second time), if necessary. At these higher doses, the drug is still used twice a day.
As with all nitroglycerin products, it is important that your body gets a 10- to 12-hour break from the drug every day. Without this break, your body will quickly become accustomed to the effects of nitroglycerin, and the drug will become completely ineffective within 24 hours.
There are no clearly established dosing guidelines for nitroglycerin extended-release capsules, as they have not been approved by the United States Food and Drug Administration (FDA).

Nitroglycerin Dosage for Anal Fissure Treatment

Nitroglycerin 0.4% ointment (Rectiv) is approved for treating anal fissures. The standard starting dosage for Rectiv for treating pain due to anal fissures in adults is approximately one inch of ointment (375 mg of ointment, containing 1.5 mg of nitroglycerin) applied every 12 hours, for up to 3 weeks.
Usually, one inch of the ointment is first applied to the finger (which has been covered with a glove, finger cot, or plastic wrap). Then the ointment is gently applied inside the anus by inserting the finger no further than the first finger joint. If this is too painful, simply start by applying it to the outside of the anus.
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