Drug Interactions With the Nitroglycerin Patch
Drug Interactions With the Nitroglycerin Patch ExplainedThe following sections explain in detail the potentially negative reactions that can occur when nitroglycerin patches are combined with any of the drugs listed above.
Combining alcohol with the nitroglycerin patch may increase your risk for low blood pressure (hypotension). Check with your healthcare provider before drinking alcohol while using nitroglycerin patches.
Based on reports of a drug interaction with intravenous (IV) nitroglycerin, it is possible that nitroglycerin patches could decrease the level of alteplase in the bloodstream, perhaps making it less effective. In the event that you need alteplase (which is sometimes used for people who are having a heart attack, blood clots, or certain types of strokes), make sure your healthcare provider knows you have been using nitroglycerin patches.
Calcium Channel Blockers
Combining nitroglycerin patches with certain calcium channel blockers could cause dangerously low blood pressure. Your blood pressure may need to be closely monitored if you take these medications together.
Ergot medications can make the nitroglycerin patch less effective for treating chest pain (angina), and nitroglycerin patches may increase the level of ergot medications in the blood, increasing the risk for ergot side effects. In general, this combination of medications should be avoided if possible.
Phosphodiesterase Type-5 (PDE5) Inhibitors
If you are using the nitroglycerin patch, you cannot take a PDE5 inhibitor, as dangerously low blood pressure may result.
One study has suggested that people taking rosiglitazone with a nitrate, including the nitroglycerin patch, have an increased risk for poor blood flow to the heart, which may lead to a heart attack.