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Naproxen/Esomeprazole Magnesium

Drug Interactions

Naproxen/esomeprazole magnesium can potentially interact with several other medications (see Drug Interactions With Naproxen/Esomeprazole Magnesium).

What If I Take an Overdose?

An overdose with this medication may cause serious effects. Seek immediate medical attention if you or someone else may have overdosed on naproxen/esomeprazole magnesium.
(Click Vimovo Overdose for more information.)

How Does This Medication Work?

Naproxen/esomeprazole magnesium contains two different active ingredients. Naproxen belongs to a group of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). Like other NSAIDs, it works by blocking a specific enzyme known as cyclooxygenase (COX), blocking the production of various inflammatory substances in the body.
The other active ingredient (esomeprazole) belongs to a group of medications called proton pump inhibitors (PPIs). The stomach contains tiny pumps (called proton pumps) that produce acid. Esomeprazole works by binding to the proton pumps, stopping them from producing acid. PPIs are very effective at decreasing acid production, as they work directly at the acid pumps.
Naproxen is very effective, but many people cannot take naproxen because it has a tendency to cause stomach ulcers. Esomeprazole is added to this medication to help reduce the risk for ulcers.

When and How to Take It

Some general considerations to keep in mind when taking naproxen/esomeprazole magnesium include the following:
  • Naproxen/esomeprazole magnesium comes in extended-release tablets and is usually taken by mouth twice daily.
  • Take this medication at least 30 minutes before meals.
  • Do not crush, chew, break, or dissolve the tablets, as this destroys the extended-release properties.
  • For the medication to work properly, it must be taken as prescribed.
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Naproxen/Esomeprazole Magnesium Drug Information

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