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Drug Interactions With Naproxen/Esomeprazole Magnesium

Diazepam
Naproxen/esomeprazole magnesium may increase the level of diazepam in the bloodstream. You may wish to discuss this possible interaction with your healthcare provider.
 
Digoxin
Naproxen/esomeprazole magnesium may slightly increase the level of digoxin in the blood. Your healthcare provider may choose to monitor you more closely.
 
Erlotinib
Naproxen-esomeprazole magnesium may decrease the absorption of erlotinib, perhaps making it less effective. Your healthcare provider may recommend an alternative to naproxen-esomeprazole magnesium while you are taking erlotinib.
  
Iron
Naproxen/esomeprazole magnesium may decrease the absorption of iron supplements and medications, as stomach acid is necessary for iron absorption. If you need to take iron for a medical reason (such as for anemia), your healthcare provider may recommend an alternative medication.
 
Lithium
Combining lithium with naproxen/esomeprazole magnesium may increase the level of lithium in the blood, perhaps causing lithium toxicity. If you take these products together, your healthcare provider should monitor you closely to watch for this interaction.
 
Methotrexate
Naproxen/esomeprazole magnesium might increase the risk for methotrexate side effects. Check with your healthcare provider before combining these two medications.
 
"Blood Thinners"
Combining naproxen/esomeprazole magnesium with other medications that have anticoagulant, thrombolytic, or antiplatelet activity might increase the risk for bleeding, including dangerous internal bleeding. Check with your healthcare provider before taking naproxen/esomeprazole magnesium with any such medications (even nonprescription ones).
 
In addition, naproxen/esomeprazole magnesium may increase the level of cilostazol in the blood. If you must take these two medications together, your healthcare provider should consider lowering your cilostazol dosage to perhaps 50 mg twice daily.
 
Some research suggests that proton pump inhibitors (PPIs), like the one in naproxen/esomeprazole magnesium, may decrease the effectiveness of clopidogrel. This could potentially be a serious drug interaction. However, experts are still in disagreement about how significant this interaction really is and whether or not it affects all PPIs. Do not combine these medications without first discussing it with your healthcare provider.
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Naproxen/Esomeprazole Magnesium Drug Information

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