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Drug Interactions With Mycophenolate Sodium

Pimecrolimus
Taking mycophenolate sodium with pimecrolimus could increase your risk for potentially serious mycophenolate sodium side effects, including infection, lymphoma (cancer of the lymph nodes), and skin cancer. Although the risk for these problems is generally low, it is recommended that pimecrolimus cream not be used with medicines that suppress the immune system, including mycophenolate sodium.
 
Probenecid
Taking probenecid with mycophenolate sodium may increase the amount of mycophenolate sodium in your blood, possibly increasing your risk for side effects. Your healthcare provider may choose to monitor you more closely if you take these medicines together, and decrease your mycophenolate sodium dosage if needed.
 
Rifampin
Rifampin may decrease the amount of mycophenolate sodium in the blood, potentially making it less effective. Do not take these medicines together without first talking to your healthcare provider. If your healthcare provider recommends combining rifampin with mycophenolate sodium, he or she will likely monitor you more closely and increase your mycophenolate sodium dosage if needed.
 
Sevelamer
Sevelamer is thought to bind to mycophenolate sodium in the gut, decreasing the amount of medicine absorbed into the body. These medicines should not be taken together, if at all possible. If they are taken together, sevelamer should be taken two hours after mycophenolate sodium.
 
Sipuleucel-T
Combining mycophenolate sodium with sipuleucel-T may make sipuleucel-T less effective. Talk to your healthcare provider before taking these medicines together.
 
Tacrolimus
Taking mycophenolate sodium with tacrolimus may increase your risk for potentially serious side effects, including infection, lymphoma (cancer of the lymph nodes), and skin cancer. Do not use tacrolimus, especially the cream formulation, when taking mycophenolate sodium without first talking to your healthcare provider.
 
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