When starting memantine, dosing usually begins at 5 mg, taken once daily. Your healthcare provider will gradually increase your dosage every week until the full dose is reached. The full recommended dose of memantine is 10 mg twice a day. Memantine dosing may be lower for certain people, such as those with severe kidney problems.
The dose of memantine hydrochloride (Namenda®) that your healthcare provider recommends will vary, depending on a number of factors, including:
- How well your kidneys are functioning
- How you respond to memantine
- Other medications you may take
- Other medical conditions you may have.
As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.
Memantine Dosing for Alzheimer's DiseaseThe full recommended dose of memantine for Alzheimer's treatment is 10 mg twice daily. However, the drug should be started at a lower dose and increased slowly up to the full dose.
The starting dose of memantine is 5 mg once daily. After at least a week, your healthcare provider can increase the dose to 5 mg twice daily. After another week, your healthcare provider can again increase the dose -- to 15 mg of memantine total per day (split into two doses per day: 5 mg and 10 mg). Finally, after one more week, your healthcare provider can increase you to the full recommended dose of 10 mg twice daily.
Your healthcare provider may prescribe a memantine "titration pack," a special pack that contains enough of both strengths of the drug (5-mg and 10-mg tablets) in a clearly labeled package to help you start it easily and conveniently. This pack is used only for the first month, when your dose is being increased.
For people with severe kidney problems, the full recommended dose is lower: 5 mg twice a day.