Drug Interactions With Memantine (Cont.)

 
Carbonic Anhydrase Inhibitors
Carbonic anhydrase inhibitors make urine less acidic, which decreases the body's ability to excrete memantine through the urine. This could lead to high levels of memantine in the blood. Although this interaction is most likely to occur with carbonic anhydrase inhibitors that are taken by mouth, it is possible that carbonic anhydrase eyedrops could also cause problems.
 
Dextromethorphan
Dextromethorphan and memantine affect certain brain receptors in a similar way. Therefore, it is not known if it is safe to take these medications together. Check with your healthcare provider before combining these medications. Dextromethorphan is an active ingredient in many different prescription and non-prescription cough medications.
 
Ketamine (Ketalar)
Ketamine and memantine affect certain brain receptors in a similar way. Therefore, it is not known if it is safe to take these medications together. Make sure to check with your healthcare provider before combining ketamine and memantine.
 
Sodium Bicarbonate
Sodium bicarbonate (baking soda) makes urine less acidic, which decreases the body's ability to excrete memantine through the urine. This could lead to high levels of memantine in the blood. This is not expected to be a problem with normal consumption of sodium bicarbonate in food. However, it is likely to be a problem with a large consumption of sodium bicarbonate, such as with sodium bicarbonate tablets.
 

Final Thoughts on Drug Interactions With Memantine

It is possible that not all drug interactions with memantine were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific drug interactions that may apply to you.
 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;