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Memantine XR Dosage

When treating Alzheimer's disease with memantine XR, dosing typically starts at 7 mg once daily. However, your amount will vary, depending on how you respond to this medication, other medicines you are taking, and other medical conditions you may have. If necessary, your healthcare provider can increase the amount in increments of 7 mg each week, up to a maximum of 28 mg daily.

An Introduction to Dosing With Memantine XR

The dose of memantine XR (Namenda XR®) your healthcare provider recommends will vary, depending on a number of factors, including:
  • How you respond to memantine XR
  • Other medications you are taking
  • Other medical conditions you may have.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Memantine XR Dosage for Alzheimer's Disease

The recommended starting dose of memantine XR for Alzheimer's disease treatment is 7 mg once daily. Your healthcare provider may increase this amount gradually in increments of 7 mg. The dosage should not be increased more often than once every week. The target (and maximum) memantine XR dose is 28 mg once daily.
If you are switching from short-acting memantine 10 mg twice daily, you can switch directly to memantine XR 28 mg once daily. If you are switching from short-acting memantine 5 mg twice daily, the recommended dosage is memantine XR 14 mg once daily.

General Information on Taking Memantine XR

Some considerations to keep in mind during treatment with memantine XR include the following:
  • This medication comes in extended-release capsule form. It is taken by mouth once daily.
  • You can take a dose of memantine XR with or without food. If it bothers your stomach, try taking it with food.
  • Do not crush, chew, cut, or dissolve the extended-release capsules, as this will cause the medication to be released too quickly. You should swallow them whole.
  • If you cannot swallow the capsules whole, you may open the capsule and sprinkle the contents on a little applesauce. This should be eaten right away, without chewing.
  • Make sure to take this medication at the same time each day to keep an even level in your blood.
  • For memantine XR to work properly, it must be taken as prescribed. Do not suddenly stop taking it.
  • If you are unsure about anything related to your memantine XR dosage, please talk with your healthcare provider, nurse, or pharmacist.
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