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Using Zyloprim for Lowering Uric Acid

Sometimes, people undergoing cancer treatment (such as chemotherapy or radiation) develop high uric acid levels. This is often due to "tumor lysis syndrome," a group of problems that occurs when a large tumor is destroyed by chemotherapy or radiation. As the cancer cells are destroyed, they leak uric acid into the blood, leading to very high uric acid levels. Zyloprim can help to lower uric acid levels.
When used for preventing high uric acid levels in cancer patients, Zyloprim should only be continued when the patient is at a high risk for this problem (usually only a few days at a time).

Using Zyloprim for Kidney Stones

Zyloprim is approved for preventing recurring kidney stones in people with high uric acid levels in the urine. This medication is useful for uric acid stones as well as calcium oxalate stones (as high uric acid levels can increase the risk of calcium stones). Because taking Zyloprim is not without risks, your healthcare provider should periodically reassess your need to keep taking it for preventing kidney stones.

How Does Zyloprim Work?

The drug works by lowering uric acid levels. This helps to treat gout, as this condition is caused when the levels of uric acid become so high that crystals form inside the joint. The medication lowers uric acid levels by inhibiting xanthine oxidase, an enzyme responsible for producing uric acid in the body. By inhibiting xanthine oxidase, Zyloprim slows down the rate at which the body produces uric acid.

Zyloprim Use in Children or Teens

Zyloprim is approved for treating high uric acid levels in children with cancer. It is also sometimes used to treat a rare disease of purine metabolism in children.
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Last reviewed by: Kristi Monson, PharmD;
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