Senior Health Home > Drug Interactions With Testosterone Gel

Insulin, corticosteroids, cyclosporine, and warfarin are among the medications that may cause negative drug interactions with testosterone gel. Some of these interactions can increase your risk of serious side effects, such as low blood sugar levels, fluid retention, dangerous bleeding, or liver damage. Before using testosterone gel, talk to your healthcare provider about any other medications you are taking.

An Overview of Interactions With Testosterone Gel

Testosterone gel (AndroGel®, Fortesta™, Testim®) can potentially interact with several other medications. Some of the medicines that may lead to testosterone gel drug interactions include:
  • Insulin
  • Corticosteroids, such as:
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Orapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)

More Information on Drug Interactions With Testosterone Gel

The following sections explain in detail the potentially negative interactions that can occur when testosterone gel is combined with any of the drugs listed above.
Testosterone gel can cause a drop in blood sugar levels. Therefore, if you take insulin, you should monitor your blood sugar levels more closely when starting or stopping testosterone gel, or even when adjusting your dose. You may need to adjust your insulin dosage. Check with your healthcare provider for specific instructions for your particular situation.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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