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Synvisc-One is licensed to treat the symptoms of knee arthritis for up to six months. It is approved for people over the age of 21 and is considered a type of "viscosupplement" therapy. In some cases, a healthcare provider may use Synvisc-One off-label. For example, it is sometimes injected into joints other than the knee, but it is not approved for this use.

What Is Synvisc-One Used For?

Synvisc-One® (Hylan G-F 20) is an osteoarthritis treatment that is injected directly into the knee as a single injection. It is different from previous versions of Synvisc, which required three separate injections on different days.
Synvisc-One is used for treating arthritis of the knee in people who have not experienced adequate pain relief from medications or nondrug treatments, such as physical therapy or lifestyle changes. It is most appropriate for people who are not yet good candidates for knee replacement surgery. Synvisc-One is often used in order to delay an inevitable knee replacement.

What Is Osteoarthritis?

Osteoarthritis is the most common type of arthritis. The condition starts when cartilage becomes ragged and wears away (cartilage is the tissue that pads bones in a joint). Over time, all of the cartilage in a joint can wear away, leaving bones that rub against each other. In addition, the fluid within the joint that normally lubricates and cushions it becomes thin and less able to protect the joint, contributing to the development of osteoarthritis symptoms.
Researchers do not know the exact cause or causes of osteoarthritis. Growing older is what most often puts you at risk for this condition. Knee osteoarthritis can be linked to:
  • Having weak thigh muscles
  • Being overweight
  • Injuring or overusing the knees.
While there is no cure for this condition, there are treatments that can ease pain and improve function. Some specific treatments include:
Synvisc-One can provide pain relief for as long as six months. Once your pain returns, you may receive a repeat course of treatment if necessary.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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