Senior Health Home > Synvisc-One Side Effects

Although most people are able to tolerate Synvisc-One without any problems, reactions are possible. In clinical studies, some of the most common side effects of Synvisc-One included knee pain, fluid buildup around the knee, and knee stiffness. Knee swelling could be a sign of an infection. If you develop this side effect, notify your healthcare provider right away.

Can Synvisc-One Cause Side Effects?

As with most treatments for osteoarthritis, Synvisc-One® (Hylan G-F 20) can cause side effects. However, not everyone who receives this treatment will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Synvisc-One. Your healthcare provider can discuss a more complete list with you.)

Possible Side Effects of Synvisc-One

Synvisc-One has been studied thoroughly in clinical trials, in which people were randomly treated with either Synvisc-One or a placebo (in this case, a saline injection). This way, researchers were able to distinguish between side effects of the drug and side effects caused just by injecting a substance into the joint.
The most common Synvisc-One side effects included:
  • Knee pain -- in up to 25.2 percent of people
  • Knee stiffness -- up to 8.1 percent
  • Fluid buildup around the knee -- up to 5.7 percent
  • Knee swelling -- up to 4.1 percent
  • Knee warmth -- up to 1.6 percent.
Other possible reactions included:
  • Changes in walking gait
  • Muscle pain or muscle cramps
  • Flushing of the face
  • A rapid heart rate (tachycardia)
  • Nausea
  • Dizziness
  • Fever and/or chills
  • Headaches
  • Unusual sensations on the skin, such as tingling or pricking
  • Low blood platelets
  • Ankle swelling
  • Hemorrhoids
  • Lower back pain.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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