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Synvisc-One comes in the form of a gel-like liquid. Your healthcare provider will inject your dose of Synvisc-One directly into one knee or both knees, depending on the extent of your arthritis. The effects of one injection typically last up to six months; repeat treatments may help keep your symptoms at bay, especially if the first treatment was successful.

An Introduction to Dosing With Synvisc-One

There is only one standard recommended dose of Synvisc-One® (Hylan G-F 20), regardless of the severity of your osteoarthritis symptoms. As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Synvisc-One Dosage for Knee Osteoarthritis

The recommended Synvisc-One dose for treating osteoarthritis of the knee is a single 6-mL injection (the entire syringe) once per knee. If you have arthritis in both knees, you may choose to have them done at the same time or separately.
Although the pain relief can last up to six months, most people will experience a gradual return of pain. Repeat treatments may be beneficial, especially if Synvisc-One worked well for you the first time, since the effects are not permanent.

General Information on Using Synvisc-One

Considerations to keep in mind during treatment with Synvisc-One include the following:
  • This product comes in the form of a gel-like liquid that is injected directly into the knee joint. Your healthcare provider will administer the injections.
  • Your knee will be cleansed, and a local anesthetic will usually be injected with a small needle to help prevent pain. A larger needle will then be inserted directly into the knee joint. Your healthcare provider will "drain" fluid from the joint before switching syringes and injecting a dose of Synvisc-One.
  • The draining of the joint and the injection of Synvisc-One are done with the same needle, so you will need to be "stuck" with a needle only twice (once for the anesthetic and once for the draining and the injection). Some healthcare providers may use a topical anesthetic ("numbing cream") instead of an anesthetic injection.
  • The entire procedure is brief and is done in your healthcare provider's office.
  • If you are unsure about anything related to your Synvisc-One dosage, please talk with your doctor, nurse, or pharmacist.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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