Sorine is a medication licensed to treat various irregular heart rhythms. It is available by prescription and comes in the form of a tablet that is typically taken one to three times a day. The medication belongs to two different drug classes; it is a beta blocker and a Class III antiarrhythmic medication. Potential side effects include fatigue, dizziness, and shortness of breath.
What Is Sorine?
Sorine® (sotalol hydrochloride) is a prescription medication approved to treat various irregular heart rhythms (arrhythmias). Although other forms of sotalol (such as Betapace AF®) are approved to treat atrial fibrillation and atrial flutter, Sorine is not approved for such uses.
Sorine is made by Upsher Smith Laboratories, Inc. Generic versions are made by several manufacturers.
How Does the Medication Work?
Sorine belongs to two different classes of drugs; it is both a beta blocker and a Class III antiarrhythmic medication.
As a beta blocker, Sorine slows the heart rate and increases the amount of time that a certain area of the heart (the AV node) is not responsive to an electrical signal. This means that if an electrical signal comes too soon, which could happen with atrial fibrillation or atrial flutter, the signal will not pass on to the rest of the heart.
As a Class III antiarrhythmic medication, Sorine blocks potassium channels in the heart. This action helps to control an irregular heart rhythm.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed May8, 2009.
Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 8th ed. Philadelphia (PA): Lippincott Williams & Wilkins; 2008.
National Library of Medicine (US). Drugs and Lactation Database (LactMED). NLM Web site. Available at: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT. Accessed May 8, 2009.
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