Because several nitroglycerin products are available, dosing guidelines will vary depending on the particular product used and how you respond to the medicine. When using the short-acting forms of nitroglycerin, you can use up to three doses within 15 minutes. However, seek immediate medical attention if your chest pain continues after the third dose. The long-acting forms are used on a daily basis.
Nitroglycerin tablets (Nitrostat) and spray (Nitrolingual, NitroMist) are used to treat attacks of chest pain that have already started. In general, use one spray or tablet every 5 minutes (up to three doses within 15 minutes) until the chest pain improves. If you use a third spray or tablet and your chest pain continues, it is time to seek immediate medical attention. You may be having a heart attack or other serious heart problem.
Do not use nitroglycerin more frequently or at a higher dose than absolutely necessary. Using it too often can result in a tolerance to the drug, which means your body becomes accustomed to it and no longer responds to the medication.
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