Senior Health Home > Memantine XR

Drug Interactions

Memantine XR can potentially interact with several other medicines (see Drug Interactions With Memantine XR).

Overdose Information

People who take too much memantine XR may have overdose symptoms that could include:
  • Agitation or restlessness
  • Confusion
  • Changes in heart rhythm
  • Unconsciousness
  • Psychosis (such as hallucinations or delusions)
  • Drowsiness
  • Vertigo (a spinning sensation)
  • Slow movement or an unsteady gait
  • Vomiting
  • Weakness
  • Coma.
If you happen to overdose on this or any other medication, seek immediate medical attention.
(Click Namenda XR Overdose for more information.)

What Should I Do If I Miss a Dose of Memantine XR?

If you do not take your memantine XR as scheduled, take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and continue with your regular schedule. Do not take a double dose.

How Does It Work?

Memantine XR is classified as an NMDA receptor antagonist. "NMDA" stands for N-methyl-D-asparate. It is thought that some of the symptoms of Alzheimer's may be related to changes in NMDA receptors that allow for abnormal, excessive excitation of the receptors by glutamate (a neurotransmitter brain chemical).
Memantine XR works by binding to the NMDA receptor and preventing excessive excitation by glutamate. Currently, no other Alzheimer's medications work like this one, other than the short-acting version, memantine.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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