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Your dosage of denosumab will depend on several factors, such as why you are taking the medication. When treating osteoporosis, the recommended dose is one injection (administered by a healthcare provider) every six months. For preventing cancer-related bone problems, an injection is given every four weeks. The injection is given just under the skin in the abdomen (lower stomach area), upper arm, or upper thigh.

An Introduction to Dosing With Denosumab

The recommended dosage of denosumab (Prolia®, Xgeva®) depends on which product is used (Prolia or Xgeva) and why you are taking the medication. As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.

Denosumab Dosage for Osteoporosis

The recommended dose of denosumab for osteoporosis treatment is 60 mg (1 mL) injected once every six months just under the skin in the abdomen (lower stomach area), upper arm, or upper thigh.
You should also be taking at least 1000 mg of calcium and 400 IU of vitamin D daily (or more, as your healthcare provider recommends).
The version of denosumab approved for this use is sold under the brand name Prolia.

Denosumab Dosage for Cancer-Related Bone Problems

The recommended dose of Xgeva for preventing cancer-related bone problems is 120 mg (1.7 mL) injected once every four weeks, just under the skin in the abdomen (lower stomach area), upper arm, or upper thigh.
Your healthcare provider should advise you if you need to take calcium and vitamin D (and how much of each) to prevent low blood calcium, a possible side effect of denosumab. Not everyone using this drug for cancer-related bone problems may need extra calcium and vitamin D, since sometimes cancer can actually cause high blood calcium levels.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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