Senior Health Home > Delatestryl Warnings and Precautions

Delatestryl has the potential to cause high blood calcium levels, fluid retention, and other problems. To help ensure a safe treatment process, talk to your healthcare provider before starting treatment if you have any other medical conditions. Other warnings and precautions with Delatestryl extend to pregnant women, men with breast or prostate cancer, and those with certain allergies.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to starting Delatestryl® (testosterone enanthate) if you have:
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about any medications you are taking, including prescription and nonprescription medications, vitamins, and herbal supplements.

Specific Warnings and Precautions With Delatestryl

Warnings and precautions to be aware of prior to using this drug include the following:
  • Women using Delatestryl (usually for breast cancer) should report any signs of virilization to their healthcare providers right away. Symptoms of virilization include:
    • A deepening voice
    • Body and/or facial hair
    • Clitoral enlargement
    • Menstrual irregularities.
If the medication is stopped early on, the virilization may be at least partially reversible. If it is stopped later, the virilization may be permanent. However, you and your healthcare provider may decide for you to keep using Delatestryl, despite virilization, if the benefits to you are significant.
  • Delatestryl can cause or worsen an enlarged prostate. It also appears to increase the risk of prostate cancer. Your healthcare provider should evaluate you for prostate cancer before you start the medication and periodically thereafter.
  • This medicine can potentially decrease sperm count, thereby decreasing fertility (although it can also help with certain causes of infertility related to low testosterone). Consult your healthcare provider if you experience difficulty conceiving a child while using Delatestryl.
  • Make sure to contact your healthcare provider right away if you develop symptoms of high blood calcium levels (hypercalcemia), such as:
    • Constipation, nausea, or vomiting
    • Muscle achiness or weakness
    • Kidney stones
    • Abdominal (stomach) pain or side pain
    • Confusion or lethargy
    • Increased thirst and frequent urination.
  • Androgens can increase the risk of liver problems, including liver cancer. Although these problems have not been reported with Delatestryl, they cannot be completely ruled out.
  • Androgens can cause fluid retention, which can be dangerous for people with liver, heart, or kidney disease.
  • Your healthcare provider may want to monitor your cholesterol more closely while you are on this medication.
  • Delatestryl can cause bone problems when given to adolescents. These problems can result in a shorter-than-expected stature. A healthcare provider will need to monitor the adolescent's bones at least once every six months during treatment.
  • Breast enlargement can occur in men using Delatestryl.
  • Delatestryl can worsen (or possibly even cause) sleep apnea.
  • This product can potentially react with a few other medications (see Delatestryl Drug Interactions).
  • Delatestryl is considered a pregnancy Category X medication. This means it is definitely not safe for use during pregnancy (see Delatestryl and Pregnancy).
  • This medication is not safe for use during breastfeeding (see Delatestryl and Breastfeeding).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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