Senior Health Home > Colcrys Warnings and Precautions

If you take an overdose of Colcrys or combine it with the wrong medication, there can be serious consequences. Therefore, the warnings and precautions for Colcrys should fully reviewed with your doctor; this will help ensure a safe treatment. If you have liver disease or kidney disease and are taking a CYP 3A4 inhibitor or P-glycoprotein inhibitor medication, you should avoid Colcrys altogether.

What Should I Tell My Healthcare Provider Before Taking Colcrys?

Prior to taking Colcrys® (colchicine), tell your healthcare provider if you have:
  • Kidney disease, such as kidney failure (renal failure)
  • Liver disease, such as cirrhosis, hepatitis, or liver failure
  • Any allergies, including to food, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Be sure to tell your healthcare provider about all other medicines you may be taking, including prescription and nonprescription medications, vitamins, and herbal supplements.

Specific Precautions and Warnings With Colcrys

Warnings and precautions to be aware of prior to taking Colcrys include the following:
  • Colcrys can interact quite seriously with a number of medications. Fatal drug interactions are possible. Therefore, it is critical that your healthcare provider always knows exactly which medications you are taking (see Colcrys Drug Interactions for more information).
  • Overdoses with this medication can be fatal. Be especially careful to keep Colcrys out of the reach of children and pets (see Colchicine Overdose for more information).
  • Colcrys can cause low levels of various types of blood cells. This may include anemia, low blood platelets, or low white blood cells. Serious problems may result.
  • This drug can cause nerve and/or muscle problems that can sometimes be serious if left untreated. Let your healthcare provider know if you experience any unusual sensations (such as burning, numbness, or tingling), especially in the hands or feet. Also, let your healthcare provider know if you develop any muscle weakness or tenderness. Elderly people seem to be at a higher risk for such problems.
  • If you have liver or kidney disease, you may need a lower-than-normal Colcrys dosage.
  • Colcrys is a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are currently unknown (see Colchicine and Pregnancy for more information).
  • This medicine passes through breast milk in trace amounts. Therefore, if you are breastfeeding or planning to start, check with your healthcare provider before taking Colcrys (see Colchicine and Breastfeeding for more information).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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