Gout is one of the most painful forms of arthritis. It is caused in part by high uric acid levels (see Causes of Gout). Uric acid is a substance that results from the breakdown of purines, which are part of all human tissue and are found in many foods.
Normally, uric acid is dissolved in the blood and passed through the kidneys into the urine, where it is eliminated from the body. If the body increases its production of uric acid, or if the kidneys do not eliminate enough from the body, increased levels of uric acid build up in the blood.
Excess uric acid can form crystals in joints or other parts of the body. These crystals can lead to inflammation, causing painful gout symptoms.
Colcrys is believed to work for gout by limiting inflammation. Specifically, it is thought to inhibit certain inflammatory cells known as neutrophils that are responsible for some of the symptoms of gout. It is unclear how exactly Colcrys works for familial Mediterranean fever, although the inhibition of neutrophils or other inflammatory cells is probably involved.
Colcrys Uses in Children
Colcrys is approved for treating FMF in children as young as four years old. It is approved for treating gout in adolescents as young as 16 years old. Talk with your child's healthcare provider about the benefits and risks of using Colcrys in children.
On occasion, your healthcare provider may recommend this product for something other than the conditions listed in this article. This would be known as an "off-label" use. Possible off-label uses for Colcrys include the treatment of:
Food and Drug Administration, Center for Drug Evaluation and Research. FDA orders halt to marketing of unapproved single-ingredient oral colchicine (9/30/2010). FDA Web site. Available at: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm227796.htm. Accessed October 8, 2010.
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