Senior Health Home > Side Effects of Alendronate and Cholecalciferol

In clinical studies, some of the most commonly reported side effects of alendronate and cholecalciferol include abdominal pain, indigestion, and constipation. Side effects are generally mild and easily treated. However, potentially serious alendronate and cholecalciferol side effects that should be reported to a healthcare provider immediately include throat or chest pain, jaw or tooth problems, and signs of an allergic reaction.

Side Effects of Alendronate and Cholecalciferol: An Introduction

As with any medicine, side effects are possible with alendronate and cholecalciferol (Fosamax Plus D™); however, not everyone who takes the medication will experience side effects. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with alendronate and cholecalciferol. Your healthcare provider can discuss a more complete list of alendronate and cholecalciferol side effects with you.)

Serious Side Effects of Alendronate and Cholecalciferol

Some side effects with alendronate and cholecalciferol, while occurring infrequently, are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
  • Throat pain, chest pain, or difficulty swallowing (which may be signs of ulcers of the esophagus)
  • Severe heartburn or heartburn that does not go away
  • Severe bone, muscle, or joint pain
  • Jaw or tooth problems
  • Groin or thigh pain, as these might be symptoms of a rare type of broken bone that has been reported with medications like alendronate and cholecalciferol 
  • Signs of an allergic reaction, including unexplained rash, hives, itching, and unexplained swelling.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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