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Alendronate and cholecalciferol is a combination medicine used for treating osteoporosis in men and postmenopausal women. It consists of a bisphosphonate and vitamin D, both of which are important in slowing down the rate at which bone breaks down. Alendronate and cholecalciferol tablets are available by prescription and are taken weekly. Potential side effects include indigestion, bone pain, and abdominal pain.

What Is Alendronate and Cholecalciferol?

Alendronate and cholecalciferol (Fosamax Plus D™) is a prescription medication approved to treat osteoporosis in men and postmenopausal women.
(Click What Is Alendronate and Cholecalciferol Used For? for more information, including possible off-label uses.)

Alendronate and Cholecalciferol Side Effects

As with any medicine, side effects are possible with alendronate and cholecalciferol. However, not everyone who takes the drug will experience side effects. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider. Serious side effects are less common.
Common side effects of alendronate and cholecalciferol include but are not limited to:
  • Abdominal pain (stomach pain)
  • Bone, muscle, or joint pain
  • Indigestion or heartburn.
(Click Side Effects of Alendronate and Cholecalciferol to learn more, including potentially serious side effects that you should report immediately to your healthcare provider.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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