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Precautions and Warnings With Ketoconazole Gel

Ketoconazole gel can cause allergic skin reactions and other skin problems. Although many people respond well to ketoconazole gel, there are some people who should not use this product. For example, people who have certain allergies need to carefully review the safety warnings associated with ketoconazole gel. Other precautions extend to women who are pregnant or breastfeeding.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to using ketoconazole gel (Xolegel®) if you:
  • Are pregnant or thinking of becoming pregnant
  • Are breastfeeding
  • Have any allergies, including to foods, dyes, or preservatives.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Ketoconazole Gel Precautions and Warnings

Some warnings and precautions to be aware of prior to using this product include the following:
  • Large oral doses of ketoconazole (the active ingredient in ketoconazole gel) can cause liver problems and hormonal imbalances, although these problems have not been seen with ketoconazole products applied to the skin like ketoconazole gel.
  • Ketoconazole gel can cause allergic reactions or other skin reactions. Let your healthcare provider know if you have new or different skin problems while using this medication. Also, let him or her know if your seborrhea does not improve or seems to be getting worse.
  • The gel is flammable. Avoid flames or smoking while applying the medication and immediately afterwards. Do not puncture the can or expose it to high temperatures.
  • Ketoconazole gel is a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are currently unknown (see Xolegel and Pregnancy).
  • It is unknown if ketoconazole gel is safe for use while breastfeeding. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to using this product (see Xolegel and Breastfeeding).
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Ketoconazole Gel Information

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