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Precautions and Warnings With Hylan G-F 20

There are many warnings and precautions with hylan G-F 20 to be aware of before starting treatment. This product may not be suitable for everyone; you could be allergic to it if you are allergic to any bird products (since it is made from chicken combs). Hylan G-F 20 should not be injected into the bloodstream or anywhere else except the knee joint.

What Should I Tell My Healthcare Provider Before Taking Hylan G-F 20?

You should talk with your healthcare provider prior to taking hylan G-F 20 (Synvisc®, Synvisc-One®) if you have:
  • A swollen leg, ankle, or foot
  • An infection in or around the knee
  • Any allergies, including allergies to food, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking about becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Hylan G-F 20 Warnings and Precautions

Warnings and precautions to be aware of prior to taking hylan G-F 20 include the following:
  • If you are allergic to any bird products, such as feathers or eggs, you might also be allergic to hylan G-F 20, since it is made from chicken combs.
  • Your healthcare provider should not inject any medications (such as steroids or anesthetics) into the knee joint along with hylan G-F 20, as this would dilute the product and make it less effective. It is okay for your healthcare provider to inject a local anesthetic to help numb the area prior to the injection.
  • In the United States, hylan G-F 20 is not approved for injection into any other joint except the knees.
  • This product should not be injected into the bloodstream or anywhere else except the knee joint.
  • Hylan G-F 20 should be used with caution if you have swelling of the leg, ankle, or foot.
  • It is unknown if hylan G-F 20 passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to beginning treatment (see Synvisc and Breastfeeding).
  • It is not known if hylan G-F 20 is safe for use during pregnancy (see Synvisc and Pregnancy).
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