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Hylan G-F 20

Hylan G-F 20 is approved for people with osteoarthritis of the knee who have not experienced adequate pain relief from medications. It is a gel-like liquid that is injected directly into the knee joint to provide cushioning and lubrication for the joint. This product can relieve pain for up to six months. Common side effects include knee pain and knee swelling.

What Is Hylan G-F 20?

Hylan G-F 20 (Synvisc®, Synvisc-One®) is an osteoarthritis treatment that is injected directly into the knee to cushion and lubricate the joint. Such treatments are known as viscosupplements. Synvisc is given as three separate injections (each one week apart), while Synvisc-One is given as a single injection. Both versions help to relieve pain for up to six months.
This product is most appropriate for individuals who have not received adequate pain relief from other arthritis treatments (such as medications) but who are not yet good candidates for knee replacement surgery.
(Click What Is Hylan G-F 20 Used For? for more information, including possible off-label uses.)

Potential Side Effects

Hylan G-F 20 can cause side effects. However, not everyone who receives the treatment will experience problems. Most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider. Serious side effects are less common.
Possible hylan G-F 20 side effects include but are not limited to:
  • Knee pain
  • Knee swelling
  • Fluid build-up around the knee.
(Click Side Effects of Hylan G-F 20 to learn more, including potentially serious side effects you should report immediately to your healthcare provider.)
The Dirty, Messy Part of BPH

Hylan G-F 20 Drug Information

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