Side Effects of Glucosamine and Chondroitin

Constipation, drowsiness, and heartburn are some of the side effects that have been reported with glucosamine. Chondroitin side effects may include nausea, hair loss, and diarrhea. Potentially serious side effects of the supplement include heart palpitations and swollen eyelids. It is important to notify your healthcare provider immediately if you experience any possible side effects of glucosamine and chondroitin (however minor they may seem).

Can Glucosamine and Chondroitin Cause Side Effects?

Glucosamine and chondroitin are dietary supplements used most often for treating arthritis. In general, these supplements are not likely to cause significant side effects in most people. However, some side effects have been reported.
 
(This article covers many, but not all, of the possible side effects with glucosamine and chondroitin. Your healthcare provider can discuss a more complete list of side effects with you.)
 

Possible Side Effects

Side effects of glucosamine reported in studies include:
 
 
Side effects of chondroitin reported in studies include:
 
  • Nausea
  • Pain in the middle upper abdomen (such as what you might feel with acid reflux)
  • Diarrhea
  • Constipation
  • Swollen eyelids
  • Swollen ankles or feet
  • Hair loss
  • Heart palpitations or feeling that your heart skipped a beat.
     
Side Effects of Glucosamine and Chondroitin Article Continues on Next Page >
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD
 
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