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Drug Interactions With Glucosamine and Chondroitin
Diabetes medications, anticoagulant or antiplatelet drugs, acetaminophen, and certain chemotherapy drugs may cause glucosamine and chondroitin drug interactions. These interactions are potentially serious and could lead to reduced effectiveness of the medicines, increased blood sugar, or increased risk of bleeding.
Glucosamine and chondroitin supplements can potentially interact with several medicines. Some of these medicines that may lead to glucosamine and chondroitin drug interactions include:
- Acetaminophen (Tylenol®)
- Certain chemotherapy drugs, such as:
- Etoposide (Toposar®, VePesid®)
- Teniposide (Vumon®)
- Doxorubicin (Adriamycin®, Doxil®)
- Diabetes medications
- Medications that "thin" the blood (such as anticoagulant and antiplatelet drugs), such as:
- Antithrombin (ATryn®, Thrombate III®)
- Argatroban
- Aspirin (Bayer® and others)
- Bivalirudin (Angiomax®)
- Cilostazol (Pletal®)
- Clopidogrel (Plavix®)
- Dabigatran etexilate mesylate (Pradaxa®)
- Dipyridamole (Persantine®)
- Drotrecogin alfa (Xigris®)
- Eptifibatide (Integrilin®)
- Fondaparinux (Arixtra®)
- Heparin or heparin-like products, including dalteparin (Fragmin®), enoxaparin (Lovenox®), or tinzaparin (Innohep®)
- Lepirudin (Refludan®)
- Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
- Celecoxib (Celebrex®)
- Diclofenac (Cambia™, Cataflam®, Flector®, Solaraze® Gel, Voltaren®, Voltaren® Gel, Voltaren®-XR, Voltaren Ophthalmic®, Zipsor™)
- Ibuprofen (Motrin®, Advil®, Nuprin®)
- Indomethacin (Indocin®, Indocin SR®)
- Ketoprofen (Orudis®, Actron®, Oruvail®)
- Ketorolac (Toradol®)
- Meloxicam (Mobic®)
- Naproxen (Naprosyn®) or naproxen sodium (Aleve®, Anaprox®, Naprelan®)
- Several others (see List of NSAIDs for a more complete list of these medications)
- Thrombolytics, such as:
- Alteplase (Activase®)
- Reteplase (Retavase®)
- Streptokinase (Streptase®)
- Tenecteplase (TNKase®)
- Ticagrelor (Brilinta™)
- Ticlopidine (Ticlid®)
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD