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Drug Interactions With Glucosamine and Chondroitin

Glucosamine and Chondroitin Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when glucosamine and chondroitin is combined with any of the drugs listed above.
There have been reports that adding glucosamine to acetaminophen may reduce the pain-relieving effects of acetaminophen. This is predicted to be more of a problem with glucosamine sulfate, compared with glucosamine and chondroitin hydrochloride or N-acetyl glucosamine and chondroitin. Either way, it is probably a relatively minor drug interaction that probably does not cause problems for most people.
Certain Chemotherapy Drugs
Theoretically, glucosamine might enhance the ability of cancer cells to resist chemotherapy medications. If you are undergoing chemotherapy treatments, be sure to check with your oncologist before taking glucosamine and chondroitin.
Diabetes Medications
Theoretically, glucosamine might decrease insulin production or increase the body's resistance to the effects of insulin. Both of these actions could result in high blood sugar (hyperglycemia). However, studies generally show that this is probably not a problem for most people. It might be a good idea to check your blood sugar more often when starting or stopping glucosamine and chondroitin, just to be sure.
Medications That "Thin" the Blood
Theoretically, chondroitin might increase the risk of bleeding due to anticoagulant and antiplatelet drugs. It is not clear if this is a true risk, though. Because chondroitin is usually taken in combination with one or more other dietary supplements (such as glucosamine), it is difficult to know for sure if case reports of possible problems really indicate that chondroitin increases the risk of bleeding (since the interaction might be due to one of the other supplements).
Be sure to check with your healthcare provider before combining chondroitin with an anticoagulant or antiplatelet drug. Your healthcare provider may advise against taking the supplement or might want to monitor you more closely, to check for any possible interaction.
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